Efficacy of Fluoroquinolones against Leptospira in a Hamster Model 1 2
نویسندگان
چکیده
45 Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their ability to prevent 46 mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar 47 Portlandvere. Each agent produced a statistically significant survival advantage when 48 compared to no treatment and demonstrated survival similar to that seen with 49 doxycycline therapy. 50 51 52 53 54 55 56 57 58 59 60
منابع مشابه
Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model.
Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy.
متن کاملEfficacy of the Rabbit Polyclonal Anti-leptospira Antibody against Homotype or Heterotype Leptospira Infection in Hamster
Leptospirosis, caused by Leptospira, is one of the most important of neglected emerging zoonotic diseases that has important impacts on public health worldwide. Polyclonal antibody (pcAb) therapy is a potential method to process a series of pathogens for which there are limited determination of treatment, such as leptospirosis. First, we evaluated the efficacy of pcAb, derived from the sera of ...
متن کاملCharacterization of virulence of Leptospira isolates in a hamster model.
Effort has been made to identify protective antigens in order to develop a recombinant vaccine against leptospirosis. Several attempts failed to conclusively demonstrate efficacy of vaccine candidates due to the lack of an appropriate model of lethal leptospirosis. The purposes of our study were: (i) to test the virulence of leptospiral isolates from Brazil, which are representative of importan...
متن کاملA prime-boost strategy using the novel vaccine candidate, LemA, protects hamsters against leptospirosis.
Toward developing an effective vaccine capable of conferring heterologous protection, the putative lipoprotein LemA, which presents an M3 epitope similar to that of Listeria, was evaluated as a vaccine candidate in the hamster model of leptospirosis. LemA is conserved (>70% pairwise identity) among the pathogenic Leptospira spp., indicating its potential in stimulating a cross-protective immune...
متن کاملLigB subunit vaccine confers sterile immunity against challenge in the hamster model of leptospirosis
Neglected tropical diseases, including zoonoses such as leptospirosis, have a major impact on rural and poor urban communities, particularly in developing countries. This has led to major investment in antipoverty vaccines that focus on diseases that influence public health and thereby productivity. While the true, global, impact of leptospirosis is unknown due to the lack of adequate laborator...
متن کامل